VERTICAL GRANULATION IN A HIGH SHEAR MIXER
Wet granulation of solids is one of the key manufacturing steps, particularly in the production of tablet formulations. In this process, small, powdery particles are combined into granules with the addition of a granulating liquid (e.g. water, PVP solution, etc.). Vertical high-shear mixers have become established in the pharmaceutical industry as a suitable granulation technology. After wet granulation, the granules are usually transferred to a fluid bed dryer for drying.
In addition to their use in the pharmaceutical industry, vertical high shear mixers can also be used for a wide range of cosmetic and food products. They are particularly easy to access and clean.
THE GRANULATION PROCESS IN A VERTICAL HIGH SHEAR MIXER
- Mixing:
The powdery raw materials are brought into a vortex and intensively mixed by means of the mixing tool rotating close to the bottom of the mixing drum. - Mositure addition:
A defined amount of granulation liquid (e.g. water or PVP solution) is added after the mixing process. The liquid is added into the effective area of the chopper to ensure optimum liquid distribution. - Granulation:
The individual product particles are moistened and bonded together, gradually forming granules. The dynamics of the vortex-like product movement and the shape of the mixing tools assist this process. The granule size can be calibrated by using a sieve while discharging the product from the high shear mixer. - Granulate dryings:
After granulation, the granules are usually dried to remove excess moisture. This drying process usually takes place in a fluid bed dryer.
OUR SOLUTIONS FOR VERTICAL GRANULATION
We provide solutions for a wide range of applications when it comes to granulation in vertical high shear mixers. Whether you need a machine for laboratory use, are looking for a machine to granulate tablet masses or want to process food products: Our high shear mixers are as diverse as our customers' applications. In addition to GMP-compliant basic equipment, our machines and systems are available with many additional options.
Mixing granulator (Laboratory machine)
- Laboratory mixing granulator with exchangeable vessel
- Mixing, granulation and temperature control in one machine
- Exchangeable vessels with a volume of 1, 5, 10 or 15 l
- GMP-compliant design
- User-friendly, integrated control system
- Operation-ready system
THE LÖDIGE MIXING GRANULATOR
- Mixing granulator for pharmaceutical products, cosmetics and food
- GMP-compliant design
- Modular WIP system for the machine and all additional components
- Automatic liquid addition in different versions
- New pharmaceutical controls
- Temperature control jacket for heating/cooling
- Integrated sieve on machine outlet
- Vacuum feeder
- Customised ATEX concepts
NO SUITABLE MACHINE FOUND?
SERVICES RELATED TO THE GRANULATION PROCESS
We place great emphasis on working in partnership with our customers to develop and implement ideal project concepts. In order to achieve optimum and efficient production results, we offer all the services required for our machine programme. These range from process development, engineering and manufacturing to plant construction, on-site installation, maintenance and repair.
WE ARE CERTIFIED & APPROVED
Our commitment to quality is officially confirmed by recognised testing bodies. Find out more here about our industry-specific approvals and certificates.
CONTACT US NOW
Do you have any questions or need assistance? Find the right contact at LÖDIGE for your specific request. Our team is ready to assist you with expertise and customised solutions. Contact us today and start your project with the ideal partner for mixing, drying, granulating, coating and reacting.